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Wladek Minor, Ph.D
Professor
Image from http://krzys.med.virginia.edu/CrystUVa/wladek.htm
Address:
Phone office: 434-243-6865
Phone Lab: 434-924-2948
e-mail: wladek {at} iwonka {-dot-} med {-dot-} virginia {-dot-} edu
Department of Molecular Physiology
and Biological Physics
University of Virginia
1300 Jefferson Park Avenue,
Jordan Hall
Room 4223
Charlottesville, VA 22908
Research interest:
Our laboratory studies macromolecular structure with an aim toward in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and biochemical methods of analysis. The program emphasizes two broad themes: crystallographic studies on molecules of immediate interest, and methodology development. Most of the macromolecules that we have under study relate to one or more of a few broad biological areas: cellular signal transduction and metalloproteins. The same systems have been chosen as subjects for methodology development. The methodology development includes the development of various crystallographic tools that create the HKL package. Another research area is high-throughout crystallography and structural genomics.
Education and awards:
N/A
Selected and Recent publications:
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Segraves EN, Chruszcz M, Neidig ML, Ruddat V, Zhou J, Wecksler AT, Minor W, Solomon EI, Holman TR.
Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly.
Biochemistry. 2006 Aug 29;45(34):10233-42.
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Minor W, Cymborowski M, Otwinowski Z, Chruszcz M.
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes.
Acta Crystallogr D Biol Crystallogr. 2006 Aug;62(Pt 8):859-66.
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Kirillova O, Minor W.
Map2mod--a server for evaluation of crystallographic models and their agreement with electron density maps.
Bioinformatics. 2006 Jul 1;22(13):1660-1.
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Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH.
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.
Cancer Cell. 2006 Apr;9(4):249-60.
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Murphy TA, Catto LE, Halford SE, Hadfield AT, Minor W, Walsh TR, Spencer J.
Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases.
J Mol Biol. 2006 Mar 31;357(3):890-903.
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Dominiak PM, Makal A, Mallinson PR, Trzcinska K, Eilmes J, Grech E, Chruszcz M, Minor W, Wozniak K.
Continua of interactions between pairs of atoms in molecular crystals.
Chemistry. 2006 Feb 20;12(7):1941-9.
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Flanagan JF, Mi LZ, Chruszcz M, Cymborowski M, Clines KL, Kim Y, Minor W, Rastinejad F, Khorasanizadeh S.
Double chromodomains cooperate to recognize the methylated histone H3 tail.
Nature. 2005 Dec 22;438(7071):1181-5
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Lovelace LL, Minor W, Lebioda L.
Structure of human thymidylate synthase under low-salt conditions.
Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):622-7.
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Chruszcz M, Cymborowski M, Gawlicka-Chruszcz A, Yasukawa S, Ferrara JD, Minor W.
L-Methioninium chloride and L-selenomethioninium chloride at 103 K.
Acta Crystallogr C. 2004 Dec;60(Pt 12):o868-71.
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Otwinowski Z. and Minor W.,
Processing of X-ray Diffraction Data Collected in Oscillation Mode
Methods in Enzymology, Volume 276: Macromolecular Crystallography, part A, p.307-326, 1997,C.W. Carter, Jr. & R. M. Sweet, Eds.,
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Minor W, Tomchick D, Otwinowski Z.
Strategies for macromolecular synchrotron crystallography.
Structure 2000, 8:R105-R110
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Z. Otwinowski and W.Minor,
Denzo and Scalepack
International Tables for Crystallography, Volume F: Macromolecular Crystallography
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W.Minor and Z. Otwinowski
Advances in Accuracy and Automation of Data Collection and Processing
Proceedings of IUCr Computing School, Bellingham, 1966
This information was correct at 01 Jan 2007
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