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Re: [ccp4bb] Cocrystals - should they pop up under native conditions? |
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CCP4bb navigationCCP4bb <-- 2008 <-- January 2008 <-- 23 January 2008Subject: Re: Cocrystals - should they pop up under native conditions? From: CCP4 ccp4hnaalas {- at -} GMAIL {- dot -} COM Date: 2008-01-23 > I am running co crystallisation experiments and have thus far been > trying under > oil screens with some success (i.e. various hits in various conditions > resulting in crystal growth). These conditions have varied from > the native > condition up until now. Do you already have the structure of the native form? If so, you can look at the putative binding region of your ligand, and check whereas it is involved in crystal packing or not. In any case, you'll have to shoot them and look at the density for confirmation; but just to have an idea of what "worth can be expected". HTH Kind regards. Leo ------------------------------------------------------------ Chavas Leonard, Ph.D. Research Associate ------------------------------------------------------------ Faculty of Life Sciences The University of Manchester The Michael Smith Building Oxford Road Manchester Lancashire M13 9PT ------------------------------------------------------------ Tel: +44(0)161-275-1586 e-mail: Leonard.Chavas@manchester.ac.uk CCP4bb navigationCCP4bb <-- 2008 <-- January 2008 <-- 23 January 2008 |
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