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[ccp4bb] Influenza M2 proton channel structures |
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CCP4bb navigationCCP4bb <-- 2008 <-- February 2008 <-- 05 February 2008Subject: Influenza M2 proton channel structures From: "Mark J {- dot -} van Raaij" vanraaij {- at -} USC {- dot -} ES Date: 2008-02-05 In the latest Nature (which for once arrived in a few days to our office...) there are interesting structures of the influenza M2 proton channel. One is by NMR, which resulted in a model of a closed state with four inhibitor molecules bound to the outside. Another is by X-ray crystallography, where an open state is observed. The x-ray structure is at 2 Angstrom without inhibitor, and they include a complex with the inhibitor at 3.5 Angstrom, where the inhibitor is modelled in positive difference density inside the pore. Drug-resistant mutations are near the binding site proposed in the X-ray paper, but the resolution is limited (3.5 Angstrom). The NMR paper also explains the drug- resistant mutations, but perhaps less convincingly. With the current evidence, which is more convincing? Or could both be "true"? Of course, we can always say we should wait for more evidence, like a higher-resolution X-ray structure or more biochemical data. In any case, I am curious to hear the opinions of other structural biologists. Carnaval greetings, Mark van Raaij CCP4bb navigationCCP4bb <-- 2008 <-- February 2008 <-- 05 February 2008 |
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